Save Time & Reduce Risk by Outsourcing Mitomycin

You are probably using Mitomycin C for various procedures, most often reconstituting it for ophthalmic, urologic, and chemotherapy treatment. Since it is a cytotoxic agent, proper procedures must be taken to prevent exposure to the drug during reconstitution.   This common but hazardous process has prompted some surgery centers to outsource compounded mitomycin. To make matters worse, mitomycin is on national back order, prompting many more surgery centers to consider outsourcing. 

Save Time

There are some distinct advantages if you outsource mitomycin for your ophthalmic and urologic cases.  The mitomycin will arrive at the facility in solution ready for administration to the patient.  You don’t need to manipulate the product beyond taking the cap off and placing a needle or urethral tip on the syringe.  Stability is another benefit.  Verified data shows that the mitocycin JCB reconstitutes in syringes is stable for 42 days when refrigerated and 11 days at room temperature.  This stability allows you to have several weeks supply on hand rather than ordering within a couple days of every procedure. 

Reduce Risk

What are the drawbacks to outsourcing?  (1.) Be prudent when choosing your sterile product pharmacy.  Some outsourcers have supplied frozen mitomycin.  Be aware that current literature does not support storage of mitomycin in a frozen state.  Studies show that when frozen, mitomycin will form a fine, pink, needle-like precipitate that does not dissolve when thawed in a microwave.   Precipitate in the product can cause physical damage to the eye or pain upon injection or instillation in the bladder.  (2.) Your outsourcing pharmacy should package the mitomycin in bags clearly marked with cytotoxic labeling.  Make sure all your personnel understand the hazardous nature of the drug and how to properly handle the product.  (3.) Finally, be sure to dispose mitomycin waste properly in yellow cytotoxic waste containers.  You can then contact hazardous material disposal companies to pick up the containers and provide documentation of proper disposal.

Outsourcing Mitomycin can be a time and risk saving measure.  Just make sure your outsourcer is familiar with proper preparation, storage and packaging.

Written by Newport Beach Compounding Center Staff

As one of the most experienced compounding pharmacies in Newport Beach, We provide a valuable service working together with physicians and patients to create medications tailored to specific requirements. We are specialists in the art and science of pharmacy compounding. Our Team of experts can meet all of your unique pharmaceutical needs.

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